Indications

The treatment of infections caused by tetracycline-sensitive organisms e.g.:

• Borrellia recurrentis (relapsing fever)
  
  
• Chlamydia species (psittacosis, lymphogranuloma venerium, trachoma, salpingitis, urethritis)
  
  
• Haemophilus ducreyi (chancroid)
  
  
• Leptospira in penicillin hypersensitivity as an alternative to erythromycin (meningitis, jaundice)
  
  
• Mycoplasma pneumoniae (granuloma inguinale)
  
  
• Rickettsiae (typhus fever, Q fever, rocky mountain spotted fever)
  
  
• Vibrio species (cholera)
  
  

Indications

• Chloramphenicol is a bacteriostatic antibiotic with a broad spectrum of action against both Gram-positive and Gram-negative bacteria, as well as some other organisms.
  
  
• Chloramphenicol is indicated in:
  - Severe typhoid and other salmonella infections.
  - Bacterial meningitis, especially against Haemophilus   influenza, Streptococcus peneumoniae and Neisseria   meningitis
  
  
• Severe anaerobic infections, particularly in brain abscesses, and in infections below the diaphragm where Bacteroides fragilis is often implicated
  
  
• Typhus and the spotted fevers
  
  
• Anthrax, severe systemic infections, severe gastro-enteritis and gas gangrene
  
  
• It is a cost effective antibiotic, although effect on bone marrow should be borne in mind during long-term oral therapy
  
  

Indications

• Gentamicin is an aminoglycoside antibiotic used, usually in combination, to treat severe systemic infections due to Gram-negative, some Gram-positive and other organisms.
  
  
• Intermediate activity against Pseudomonas, although needs to be combined with metronidazole to cover anaerobic bacteria.